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Reducing Antibiotic Use for Uncomplicated Urinary Tract Infection in General Practice by Treatment with Uva-Ursi (REGATTA) – A Double-Blind, Randomized, Controlled Comparative Effectiveness Trial

Uncomplicated urinary tract infections (UTI) are common in general practice and usually treated with antibiotics. This contributes to increasing resistance rates of uropathogenic bacteria. A previous trial showed a reduction of antibiotic use in women with UTI by initial symptomatic treatment with ibuprofen. However, this treatment strategy is not suitable for all women equally. Arctostaphylos uva-ursi (UU, bearberry extract arbutin) is a potential alternative treatment. This study aims at investigating whether an initial treatment with UU in women with UTI can reduce antibiotic use without significantly increasing the symptom burden or rate of complications. Read more here.