Complementary and alternative medicine (CAM) has been presented in the sociological literature as a global phenomenon. Yet CAM has simultaneously been shaped by different ‘civic epistemologies’, or national cultures, and re-embedded into local contexts. This ‘glocalism’ of CAM, in turn, is a result of intercultural exchanges over time. This chapter compares CAM practice and regulation in two countries with a long-standing relationship—Brazil and Portugal. Homeopathy, acupuncture and traditional Chinese medicine have been chosen as case studies.